Fantasy football managers face crucial roster decisions every week, but the stakes are even higher in Week 10 with many key players dealing with injuries and tough matchups on tap. To help you set the optimal lineup, our team of ESPN Fantasy experts has compiled the ultimate Week 10 cheat sheet loaded with start/sit advice, injury updates, betting insights and more.
Key Start/Sit Recommendations
According to consensus rankings from the ESPN Fantasy staff, here are some of the most important players to start and sit in Week 10:
Start ‘Em
- Tony Pollard (RB, Cowboys) – With Ezekiel Elliott out, Pollard is a high-end RB1 against a vulnerable Packers run defense
- DeAndre Hopkins (WR, Cardinals) – Averaging 11 targets per game, Hopkins is a must-start even in a tough matchup vs. the Rams
- Dallas Goedert (TE, Eagles) – Goedert has a dream matchup against a Commanders defense allowing the most fantasy points to tight ends
Sit ‘Em
- Russell Wilson (QB, Broncos) – Coming off a bye, Wilson still isn’t startable against the stingy Titans defense
- Michael Carter (RB, Jets) – Carter’s workload has evaporated with James Robinson’s emergence
- Drake London (WR, Falcons) – The rookie has faded badly, failing to top 40 yards in his last 4 games
Injury Impact
Injuries to monitor heading into Week 10 include:
- Ja’Marr Chase (WR, Bengals) – Likely out again, elevating Tee Higgins to WR1 status
- Gus Edwards (RB, Ravens) – Could return to a committee with Kenyan Drake
- Jonathan Taylor (RB, Colts) – Game-time decision, with Deon Jackson a potential plug-and-play
Sneaky Sleepers
Under-the-radar players with favorable Week 10 matchups include:
- Greg Dulcich (TE, Broncos) – Emerging as a reliable target for Russell Wilson
- Kadarius Toney (WR, Chiefs) – Electric playmaker should be more involved coming off bye
- Jaylen Warren (RB, Steelers) – Carved out a consistent complementary role alongside Najee Harris
Matchups to Exploit
Some of the most favorable matchups for skill players in Week 10 are:
- Justin Fields (QB, Bears) vs. Lions’ 32nd-ranked pass defense
- Rhamondre Stevenson (RB, Patriots) vs. Colts’ league-worst run defense
- Chris Olave (WR, Saints) vs. Steelers’ injury-depleted secondary
Betting Insights
According to ESPN Analytics, the games with the highest projected point totals include:
| Matchup | Over/Under |
| Lions vs. Bears | 48.5 |
| Chiefs vs. Jaguars | 50.5 |
| Dolphins vs. Browns | 48.5 |
Fantasy managers should target players from these potential shootouts for ceiling performances.
Putting It All Together
Crafting the perfect fantasy football lineup for Week 10 requires weighing all these key factors – expected workloads, matchups, injury concerns, and scoring potential. The experts’ consensus advice distilled in this cheat sheet provides a solid roadmap, but managers must always stay alert to late-breaking news and trust their instincts when making the toughest start/sit calls.
By leaning on high-volume workhorses, avoiding fading stars, and capitalizing on soft matchups, you can vault to the top of your standings or solidify your playoff positioning here in the critical final third of the fantasy football season. Rest assured that our dedicated team at ESPN Fantasy will continue delivering the most accurate, comprehensive advice every single week. Best of luck in Week 10 and beyond!
