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NFL Week 10 Fantasy Football: Key Inactives and Last-Minute Updates

As NFL Week 10 kickoff approaches, fantasy football managers are scrambling to adjust their lineups based on the latest player news and game day inactives. To help you make informed decisions and gain an edge over your opponents, we’ve compiled a comprehensive report on the key players whose statuses are in question heading into today’s action.

9:30 a.m. ET Germany Game

The early kickoff in Germany features several notable players whose availability is uncertain. Jonathon Brooks, the Carolina Panthers’ running back, is questionable with a knee injury. While he was activated from the reserve list this week, he still may not be ready to play.

At tight end, Tommy Tremble is dealing with a back issue and is listed as questionable. However, his teammate Ja’Tavion Sanders was removed from the injury report and is expected to play, potentially limiting Tremble’s fantasy impact even if he suits up.

For the New York Giants, kicker Graham Gano is questionable due to a hamstring injury but has been activated from IR and should return to action in Germany. On the downside, wide receiver Darius Slayton has been ruled out with a concussion, opening the door for Wan’Dale Robinson to see increased looks from quarterback Malik Nabers.

1 p.m. ET Games

Moving on to the early afternoon slate, several key skill position players are facing injury concerns. Atlanta Falcons rookie wide receiver Drake London is questionable with a hip issue after being limited in practice all week. Be sure to monitor his status leading up to kickoff.

The Buffalo Bills’ passing game could be shorthanded, as wide receiver Amari Cooper is questionable with a wrist injury. If he plays, he should be heavily targeted along with Khalil Shakir. However, Keon Coleman has been ruled out, potentially opening up opportunities for others in the Bills’ aerial attack.

In Indianapolis, the Colts will be without their top wide receiver Michael Pittman Jr. due to a back injury. This news boosts the fantasy prospects of Josh Downs and Alec Pierce, who should see increased target shares in Pittman’s absence.

The Jacksonville Jaguars are facing significant injury concerns on both sides of the ball. Quarterback Trevor Lawrence is questionable with a shoulder issue, and all signs point to him being a risky start this week. If he can’t go, backup Mac Jones would take over under center. At running back, Keilan Robinson is questionable with a toe injury, while D’Ernest Johnson is dealing with a hamstring problem. Fortunately, Travis Etienne Jr. was removed from the injury report and should see the lion’s share of the backfield work.

According to a team insider, it’s looking increasingly likely that Mac Jones will start at quarterback for the Jaguars in Week 10 as Trevor Lawrence continues to deal with a shoulder injury sustained in last week’s game.

The New Orleans Saints’ backfield is also in flux, as Jamaal Williams is questionable with a groin injury. If he’s unable to play, look for Alvin Kamara and the versatile Taysom Hill to handle the majority of the rushing duties.

At wide receiver, the Saints will be without Cedrick Wilson Jr. (shoulder) and Chris Olave, who is likely headed to IR with a concussion that could sideline him for the remainder of the season. In their absence, Mason Tipton becomes the Saints’ top receiving option by default.

4 p.m. ET Games

As we look ahead to the late afternoon games, the marquee storyline is the expected return of San Francisco 49ers running back Christian McCaffrey. After missing time with an Achilles injury, McCaffrey is questionable but expected to make his 2024 debut. While Jordan Mason (shoulder) was also removed from the injury report and should see some touches, McCaffrey’s presence is a game-changer for fantasy managers who have been patiently awaiting his return.

The 49ers’ passing game is also dealing with some injury issues, as wide receiver Deebo Samuel Sr. is questionable with a rib injury that could limit his effectiveness if he plays. Fellow wideout Jauan Jennings was removed from the injury report and should be active, while Chris Conley has been ruled out with a hamstring problem.

In Los Angeles, Chargers running back Gus Edwards is questionable as he works his way back from an ankle injury that landed him on IR. If he’s active, he may be eased back into action, so temper your expectations for his fantasy output this week.

Sunday Night Football

The Sunday night game between the Houston Texans and an unnamed opponent features a few key injury situations to monitor. Texans rookie running back Dameon Pierce has been ruled out with a groin injury, leaving the backfield duties to veterans Joe Mixon and Dare Ogunbowale.

At wide receiver, Houston’s Nico Collins is listed as questionable with a hamstring issue. Although he practiced on a limited basis Friday, the late kickoff makes him an extremely risky fantasy option this week. If Collins is unable to play, Tank Dell, who is questionable with a back injury, would likely serve as the Texans’ top receiving threat.

The Bottom Line

As always, the best approach for fantasy managers is to stay informed and be prepared to adjust their lineups based on the latest injury news and game day inactives. Keep a close eye on the status of these key players leading up to kickoff, and don’t hesitate to pivot to a healthier option if necessary.

Remember, in the fast-paced world of NFL football, a player’s availability can change at a moment’s notice. By staying vigilant and adapting to the latest developments, you’ll give yourself the best chance to emerge victorious in your Week 10 fantasy matchups.

Stay tuned for more updates as kickoff approaches, and good luck to all the fantasy managers out there!